This chapter analyses the evolution of technological tools to improve port and maritime security, in relation to relevant regulations for their effective use and implementation on board ships and port facilities, based on the legal provisions established under the International Ship and Port Facility Security (ISPS) Code. New technology applications can contribute to reducing security threats at sea. However, international regulations and national laws are not reformed at the same speed as the evolution of technological innovation in ships and other sea-going vessels. The slow reform of regulations and laws is delaying the benefits that novel solutions might bring to the maritime industry and to the whole world in terms of maritime security. In this chapter, the authors introduce a limited number of technology applications instruments, with the use of Autonomous Underwater Vehicle (AUV) systems, similar to those used for inspection and maintenance, but combined with sensors to strengthen port and maritime security and, at the same time reduce the illegal trafficking of drugs. Desk research and relevant selected literature from this wide research field were used for the collection/analysis of the data and identification of a suitable solution. The authors suggest changes to the ISPS Code to standardize such equipment on board vessels, equating its need and significance to the Automatic Identification System (AIS), or the Long-Range Identification and Tracking (LRIT), to counter drug traffic by sea threats of the type of packages affixed to the bulbous bow of vessels, which is quite common, especially in the Latin-American region. Finally, outline future trends in drug detection on board vessels due to continuous technical improvement, which is also used by criminal ring organizations, arguing that in the same way as transnational organized crime is adapting and implementing innovative technology, governments and international organizations must also follow this adaptability to deter such security threats and improve the security of ports and oceans.